First Establishment of Trimester- and Season-Specific Serum 25(OH)D Reference Intervals in Shaanxi Pregnant Women: Addressing General Population Standard Limitations for Precise Perinatal Vitamin D Supplementation

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www.researchsquare.comSubmitted April 19, 2026

Background  Current clinical practice relies on general population reference intervals (RIs) for serum 25-hydroxyvitamin D (25(OH)D), which fail to account for pregnancy-specific physiological changes and seasonal fluctuations—leading to misclassification of deficiency/in...

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