HERCULES: an integrative deep-learning framework for predicting RNA-binding propensity and mutation effects at single-residue resolution

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www.researchsquare.comSubmitted April 30, 2026

RNA-binding proteins (RBPs) regulate essential aspects of RNA metabolism, yet accurately identifying RNA-binding domains (RBDs) and quantifying the impact of sequence variation on RNA-binding ability remain challenging. Here, we present HERCULES (Hybrid framEwoRk for RNA-binding domain loCalizat...

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