TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

Likely Human

elifesciences.orgAugust 18, 2026Submitted September 6, 2026

In a mouse model of E. coli meningitis, non-myeloid TLR4 signaling is a key determinant of the inflammatory response in all leptomeningeal cells and of the increase in vascular permeability.

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ClassificationLikely Human

ConfidenceMedium confidence

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